Clinical Trials

Clinical Research Center - Fresno (Downtown)

For more information, please contact: [email protected] 

Dermatology
Endocrinology
Principle InvestigatorStudy SponsorTitle (click for details)
Varsha Babu, MD DIABETIC KETOACIDOSIS MONITORING WITH FREESTYLE LIBRE
Hepatology
Principle InvestigatorStudy SponsorTitle (click for details)
Marina Roytman, MDMadrigal Pharmaceuticals, Inc.A Randomized Double-blind Placebo-controlled Phase 3 Study to Evaluate the Effect of Resmetirom on Liver-related Outcomes in Patients with Well-compensated (Child-Pugh A) Non-alcoholic Steatohepatitis (NASH) Cirrhosis (MAESTRO-NASH OUTCOMES)
Marina Roytman, MDIntercept Pharmaceuticals, Inc787-201: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-Escalation, Proof-of-Concept Study Evaluating the Safety, Tolerability, Efficacy and Pharmacokinetics of INT-787 in Subjects with Severe Alcohol-Associated Hepatitis
Infectious Disease
Principle InvestigatorStudy SponsorTitle (click for details)
Geetha Sivasubramanian, MDMira Vista Diagnostics, LLCMIRAVISTA NEXT GENERATION COCCIDIOIDES IGG AND IGM ANTIBODY ENZYME IMMUNOASSAY EVALUATION.
Geetha Sivasubramanian, MDClinical Outcomes Solutions, LLCStand-alone Cross-sectional Validation of a New Patient-Reported Outcome instrument for Patients with Disseminated Coccidioidomycosis
Geetha Sivasubramanian, MD Understanding barriers and facilitators for access to care in populations in Central California with Coccidioidomycosis (Valley fever) Meningitis or brain infection (Phase 1)
Geetha Sivasubramanian, MD Expanded Access IND Protocol: Use of Tecovirimat (TPOXX®) for Treatment of Human Orthopoxvirus Infections
Geetha Sivasubramanian, MD DisseminatedCoccidioidomycosis: Analysis of risk factors, clinical features, and treatment outcomes over 15 years: asingle center study
Geetha Sivasubramanian, MDF2G Ltd, Lankro Way, Eccles, Manchester M30 OLX, UKOlorofim Managed Access Programme: compassionate use for invasive fungal infections due to Lomentospora prolificans, Scedosporium spp., Aspergillus spp., and other diseases caused by mould fungi in patients lacking alternative treatment options
Geetha Sivasubramanian, MD Population Genomics of Emerging Valley Fever Fungus
Neurology
Principle InvestigatorStudy SponsorTitle (click for details)
Jason Gravano, MD Caregiver
OB/GYN
Principle InvestigatorStudy SponsorTitle (click for details)
Stephanie Gaw, MD, PhD Prospective Study of Outcomes after Infection during Pregnancy
Pediatrics
Principle InvestigatorStudy SponsorTitle (click for details)
Claire Gibson, MD Better Assessment & Responses to Croup in Kids (BARCK)
Claire Gibson, MD Lactation Study
Pulmonology
Principle InvestigatorStudy SponsorTitle (click for details)
Eyad Almasri, MDBiotest AGA randomized, placebo-controlled, double-blind, multi-center, phase III trial to assess the efficacy and safety of trimodulin (BT588) in adult hospitalized subjects with severe community-acquired pneumonia (sCAP)
Eyad Almasri, MDEagle Pharmaceuticals, IncA Randomized, Double-Blind, Placebo-Controlled Multicenter Study to Evaluate the Efficacy and Safety of CAL02 Administered Intravenously in Addition to Standard of Care in Subjects With Severe Community-Acquired Bacterial Pneumonia (SCABP)
Eyad Almasri, MDVanderbilt University Medical CenterThe ARDS, Pneumonia, and Sepsis (APS) Consortium: A Prospective Observational Study to Evaluate Phenotypes (Protocol A – Full Protocol)
Eyad Almasri, MDUniversity of MinnesotaStrategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE): Shionogi Protease Inhibitor
Mohamed Fayed, MDGenentech, IncA Two-Cohort, Phase II, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating the Efficacy and Safety of Vixarelimab Compared With Placebo in Patients With Idiopathic Pulmonary Fibrosis and in Patients With Systemic Sclerosis-Associated Interstitial Lung Disease
Mohamed Fayed, MDAstraZeneca ABA Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen (TILIA)
Mohamed Fayed, MDMannKind CorporationICoN-1: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of the Efficacy and Safety of Treatment With MNKD-101 (Clofazimine Inhalation Suspension) When Added to Guideline-Based Therapy in Participants with Pulmonary Nontuberculous Mycobacterial Infection
Mohamed Fayed, MDPfizerA Phase 4 Study Using a Test-Negative Design to Evaluate the Effectiveness of a 20-valent Pneumococcal Conjugate Vaccine Against Vaccine-type Radiologically-confirmed Community-acquired Pneumonia in Adults >/= 65 Years of Age
Mohamed Fayed, MD Expanded Access To Clofazimine
Mohamed Fayed, MD Expanded Access Program To Provide Brensocatib To Patients With Non-Cystic Fibrosis Bronchiectasis
Mohamed Fayed, MD Coccidioides fungemia: Clinical and Radiological features and Outcomes
Jose Joseph Vempilly, MD Britz Research AwardResidual Volume Reversibility in Asthma (REVOREA): The utility of Lung Volume measurements and comparison to spirometry in evaluating patients with Asthma and normal subjects
Surgery

Clinical Research Center - Clovis (Community Cancer Institute)

For more information, please contact: [email protected] 

Hematology/Oncology
Principle InvestigatorStudy SponsorTitle (click for details)
Haifaa Abdulhaq, MDUniversity of California, San FranciscoImproving Survivorship Care for Older Adults After Chemotherapy
Haifaa Abdulhaq, MDMillennium Pharmaceuticals, Inc.A Randomized, Open-Label, Phase 3 Trial of A+AVD vs. ABVD as Frontline Therapy in Patients with Advanced Classical Hodgkin Lymphoma
Haifaa Abdulhaq, MDNational Cancer Institute (NCI)A Randomized Phase III Study of Ibrutinib Plus Obinutuzumab Versus Ibrutinib plus Venetoclax and Obinutuzumab in Untreated Older Patients (≥ 65 Years of Age) with Chronic Lymphocytic Leukemia (CLL)” (NCT # NCT03737981)
Haifaa Abdulhaq, MDNational Cancer Institute (NCI)Randomized Phase II/III Study of Venetoclax (ABT199) Plus Chemoimmunotherapy for MYC/BCL2 Double-Hit and Double Expressing Lymphomas
Haifaa Abdulhaq, MDNational Cancer Institute (NCI)A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL negative B lineage Acute Lymphoblastic Leukemia in Adults
Haifaa Abdulhaq, MDNational Cancer Institute (NCI)A Phase III Randomized Trial of Steroids + Tyrosine Kinase Inhibitor (TKI) Induction With Chemotherapy or Blinatumomab for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia (ALL) in Adults
Haifaa Abdulhaq, MDEpizyme, IncSymphony-1: A Phase 1b/3 Double-Blind, Randomized, Active-Controlled, 3-Stage, Biomarker Adaptive Study Of Tazemetostat Or Placebo In Combination With Lenalidomide Plus Rituximab In Subjects With Relapsed/Refractory Follicular Lymphoma
Haifaa Abdulhaq, MDUniversity of California, DavisInvestigation of MRD in the Blood Measured by High Throughput Sequencing of T Cell Receptor Clonal Frequency in Patients with Treatment-Naïve Systemic T Cell Lymphoma Treated with a Brentuximab-Containing Regimen – A Pilot Study
Haifaa Abdulhaq, MDHoffman-LaRoche Ltd.A Phase III, Open-Label, Multicenter, Randomized Study Evaluating the Efficacy and Safety of Glofitamab in Combination With Gemcitabine Plus Oxaliplatin Versus Rituximab in Combination With Gemcitabine and Oxaliplatin in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Haifaa Abdulhaq, MDUniversity of California, DavisA Phase II Trial of the Combination of Obinutuzumab, Ibrutinib, and Venetoclax in Patients With Previously Untreated Follicular Lymphoma
Haifaa Abdulhaq, MDPfizer C1071005AN OPEN-LABEL, 3-ARM, MULTICENTER, RANDOMIZED PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ELRANATAMAB (PF-06863135) MONOTHERAPY AND ELRANATAMAB + DARATUMUMAB VERSUS DARATUMUMAB + POMALIDOMIDE + DEXAMETHASONE IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO HAVE RECEIVED AT LEAST 1 PRIOR LINE OF THERAPY INCLUDING LENALIDOMIDE AND A PROTEASOME INHIBITOR
Haifaa Abdulhaq, MDNovartis Pharmaceuticals CorporationA Phase II multicenter, open-label, single-arm dose escalation study of Asciminib monotherapy in 2nd and 1st Line Chronic Phase - Chronic Myelogenous Leukemia (ASC2ESCALATE)
Haifaa Abdulhaq, MDCelgene CorporationA Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) vs Epoetin Alfa for the Treatment of Anemia Due to Revised International Prognostic Scoring System (IPSS-R) Very Low, Low, or Intermediate-Risk Myelodysplastic Syndrome (MDS) in Erythropoiesis-Stimulating Agent (ESA)-Naive Participants Who Are Non-Transfusion Dependent (NTD): The "ELEMENT-MDS" Trial
Haifaa Abdulhaq, MDHoffman-LaRoche Ltd.A Phase III, Multicenter, Randomized, Open-Label Study Comparing the Efficacy and Safety of Glofitamab (RO7082859) in Combination With Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (Pola-R-CHP) Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma
Haifaa Abdulhaq, MDUniversity of California, DavisA Phase 2 Study of Loncastuximab Tesirine and Rituximab (Lonca-R) followed by DA-EPOCH-R in Previously Untreated High-Risk Diffuse Large B-cell Lymphoma
Haifaa Abdulhaq, MDBeOne Medicines, Ltd.Phase 3 Randomized, Open-Label, Multicenter Study of Zanubrutinib (BGB-3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
Haifaa Abdulhaq, MDIncyte CorporationA Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial Comparing the Efficacy and Safety of Tafasitamab Plus Lenalidomide in Addition to R-CHOP Versus R-CHOP in Previously Untreated, High-intermediate and High-risk Patients With Newly-diagnosed Diffuse Large B-cell Lymphoma (DLBCL)
Haifaa Abdulhaq, MDADC Therapeutics SarlA Phase 1b Open-Label Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination with Other Anti-cancer Agents in Patients with Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)
Haifaa Abdulhaq, MDPfizer C1071032A PHASE 3, OPEN-LABEL STUDY OF ELRANATAMAB MONOTHERAPY VERSUS ELOTUZUMAB, POMALIDOMIDE, DEXAMETHASONE (EPd) OR POMALIDOMIDE, BORTEZOMIB, DEXAMETHASONE (PVd) OR CARFILZOMIB, DEXAMETHASONE (Kd) IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO RECEIVED PRIOR ANTI-CD38 DIRECTED THERAPY
Haifaa Abdulhaq, MDAcrotech Biopharma LLCSPI-BEL-301: A Phase 3, Randomized, Open-Label Study Comparing the Efficacy and Safety of the Combination of Beleodaq-CHOP or Folotyn-COP to the CHOP Regimen Alone in Newly Diagnosed Patients with Peripheral T-Cell Lymphoma
Haifaa Abdulhaq, MDJanssen Research & Development, a J&J Co64407564MMY3009 A Phase 3 Randomized Study Comparing Talquetamab in Combination With Pomalidomide (Tal-P), Talquetamab in Combination With Teclistamab (TalTec), and Investigator's Choice of Either Elotuzumab, Pomalidomide, and Dexamethasone (EPd) or Pomalidomide, Bortezomib, and Dexamethasone (PVd) in Participants With Relapsed or Refractory Myeloma Who Have Received 1 to 4 Prior Lines of Therapy Including an Anti-CD38 Antibody and Lenalidomide
Haifaa Abdulhaq, MDJanssen Research & Development, a J&J Co64007957MMY3005 A Phase 3 Randomized Study Comparing Teclistamab in Combination With Daratumumab SC and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab SC and Lenalidomide (Tal-DR) Versus Daratumumab SC, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma Who Are Either Ineligible or Not Intended for Autologous Stem Cell Transplant as Initial Therapy
Haifaa Abdulhaq, MD Retrospective Review of Patients Diagnosed with Plasma Cell Leukemia Treated Within the University of California Hematologic Malignancies Consortium
Haifaa Abdulhaq, MDIterion TherapeuticsTegavivint (BC2059) Single Patient Compassionate Use Protocol
Haifaa Abdulhaq, MD Managed Access Program (MAP) Cohort Treatment Plan CCTL019B2003I to provide access for patients with out of specification leukapheresis product and/or out of specification manufactured tisagenlecleucel (CTL019; Kymriah®)
Haifaa Abdulhaq, MD Clinical, Molecular, and Socio-economic characteristics of Hispanics and non-Hispanic patients with Acute Myeloid Leukemia in The California s Central Valley
Haifaa Abdulhaq, MD Evaluating the prevalence of targeted mutations in metastatic hormone positive breast cancer in a single institution of central valley California
Haifaa Abdulhaq, MD Single Institution Review of Castleman Disease: Case Series data
Haifaa Abdulhaq, MDBritz Research AwardGenomic profile of Primary Central Nervous System Lymphoma in Central Valley
Haifaa Abdulhaq, MD High-Risk Genetic Profiles in Minorities with Multiple Myeloma
Haifaa Abdulhaq, MD Early Metabolic Changes During Induction Chemotherapy as Predictors of Minimal Residual Disease Status in Adult Acute Lymphoblastic Leukemia
Mohammed Bukari, MDAlliance for Clinical Trials in OncologyA Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (a Conjugated Anti-CD22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) With Newly Diagnosed Precursor B-Cell ALL
Mohammed Bukari, MDNovartis PharmaceuticalsA Phase III, Randomized, Double-blind Study of Ianalumab (VAY736) Versus Placebo in Addition to First-line Corticosteroids in Primary Immune Thrombocytopenia (VAYHIT1)
Mohammed Bukari, MDAbbVie IncA Prospective, Open-Label, Phase IIb/III Study to Evaluate the Risk of TLS and Optimization of the Initiation of Venetoclax in Combination With Obinutuzumab or Acalabrutinib With Different Ramp- Up Periods in Previously Untreated Subjects With CLL
Mohammed Bukari, MD Clinical and Molecular Profile of Patients with Essential Thrombocytosis (ET) in the Central Valley of California
Mohammed Bukari, MD Clinical Characteristics and Treatment Responses of Patients with Acute ITP Treated at Community Medical Center
Mohammed Bukari, MDUniversity of California, San FranciscoA Phase II Study, Evaluating the Efficacy of Montelukast in Reducing the Incidence and Severity of Monoclonal Antibodies Associated Infusion Reactions
Mohammed Bukari, MD Clinicopathologic and Genetic profile of Philadelphia Chromosome like (Ph-like) Acute B cell lymphocytic Leukemia inthe Central Valley
Mohammed Bukari, MD Quality Improvement Project to Improve Daratumumab Interference with Blood Compatibility Testing
Mohammed Bukari, MD Quality Improvement Project: Optimization of Heparin-induced Thrombocytopenia Testing and Management
Mohammed Bukari, MD Transfusion related complications in Sickle Cell Anemia
Mohammed Bukari, MD Sickle Cell Disease Quality of Life and Quality of Care Survey
Uzair Chaudhary, MDAlliance for Clinical Trials in OncologyA Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy
Uzair Chaudhary, MDNational Cancer Institute (NCI)Randomized Trial of Standard Chemotherapy Alone or Combined With Atezolizumab as Adjuvant Therapy for Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair
Uzair Chaudhary, MDNational Cancer Institute (NCI)PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab Vs. VEGF TKI Cabozantinib With Nivolumab: A Phase III Trial in Metastatic Untreated REnal Cell CancEr [PDIGREE]
Uzair Chaudhary, MDNational Cancer Institute (NCI)Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)
Uzair Chaudhary, MDAlliance for Clinical Trials in OncologyA Phase III Trial of 6 Versus 12 Treatments of Adjuvant FOLFOX Plus Celecoxib or Placebo for Patients With Resected Stage III Colon Cancer
Uzair Chaudhary, MDNational Cancer Institute (NCI)A Randomized Phase III Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer
Uzair Chaudhary, MDECOG-ACRIN Cancer Research GroupA Randomized Phase II Study of Gemcitabine and Nab-Paclitaxel Compared With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan in Older Patients With Treatment Naïve Metastatic Pancreatic Cancer (GIANT)
Uzair Chaudhary, MDNRG OncologyA Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel With or Without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer
Uzair Chaudhary, MDNational Cancer Institute (NCI)Program for the Assessment of Clinical Cancer Tests (PACCT-1): Trial Assigning Individualized Options for Treatment:The TAILORx Trial
Uzair Chaudhary, MDSWOG Cancer Research NetworkPhase III Trial of Continuous Schedule AC + G vs. Q 2 Week Schedule AC, Followed by Paclitaxel Given Either Every 2 Weeks or Weekly for 12 Weeks as Post-Operative Adjuvant Therapy in Node-Positive or High-Risk Node-Negative Breast Cancer
Uzair Chaudhary, MDSWOG Cancer Research NetworkA Double Blind Placebo-Controlled Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers in Patients With Stage 0-III Colon or Rectal Cancer, Phase III - Preventing Adenomas of the Colon With Eflornithine and Sulindac (PACES)
Uzair Chaudhary, MDNational Cancer Institute (NCI)A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients With 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer With Recurrence Score (RS) of 25 or Less. RxPONDER: A Clinical Trial Rx for Positive Node, Endocrine Responsive Breast Cancer
Uzair Chaudhary, MDMirati Therapeutics, IncA Randomized Phase 3 Study of MRTX849 in Combination with Cetuximab Versus  Chemotherapy in Patients with Advanced Colorectal Cancer with KRAS G12C Mutation with Disease Progression On or After Standard First-Line Therapy
Uzair Chaudhary, MDBristol-Myers Squibb CompanyA Phase 1/2 Study of BMS-986340 as Monotherapy and in Combination with Nivolumab or Docetaxel in Participants with Advanced Solid Tumors
Uzair Chaudhary, MDGenentech, Inc.CO44668: A Phase III, Randomized, Double-blind, Placebo-controlled Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma
Uzair Chaudhary, MD Demographic Variation in prevalence of genetic mutations in Stage IV Colon Cancer patients
Uzair Chaudhary, MD Evaluating the Clinical Utility of Circulating Tumor DNA as a Marker for Surveillance in Patients with Early-Stage Rectal Cancer
William Silveira, MDNSABP Foundation IncA Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy
OB/GYN
Surgery
Principle InvestigatorStudy SponsorTitle (click for details)
Amir Fathi, MD, FACS Association of nutritional status with survival in patients with solid tumors: A stage based analysis